2024 Fbw7 nr4a1 scd1

Fbw7 nr4a1 scd1

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August undefined, 2024

Webاصلی Redox Biology FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells. Redox Biology 2024 / 01 Vol. 38. FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells Ye, … WebMar 1, 2003 · Mechanistically, we found FBW7 inhibited the expression of stearoyl-CoA desaturase (SCD1) via inhibiting nuclear receptor subfamily 4 group A member 1 (NR4A1). SCD1 was reported to inhibit both ferroptosis and apoptosis, which was consistent with the function of FBW7 and NR4A1, another FBW7 down-regulated gene in the gene …

Organelle-specific regulation of ferroptosis - PMC

WebAug 1, 2024 · FBW7(F-box and WD repeat domain-containing 7) exerts tumor-suppressive effects by targeting the degradation of oncoproteins. In pancreatic cancer cells, FBW7 inhibits the expression of SCD1 by inhibiting NR4A1(nuclear receptor subfamily 4 group A member 1), which induces ferroptosis to exert its anticancer activity [156] . WebMechanistically, we found FBW7 inhibited the expression of stearoyl-CoA desaturase (SCD1) via inhibiting nuclear receptor subfamily 4 group A member 1 (NR4A1). SCD1 was reported to inhibit both ferroptosis and apoptosis, which was consistent with the function of FBW7 and NR4A1, another FBW7 down-regulated gene in the gene expression profiling. iss budowa

Wenyan Xu PubFacts

WebFBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase. SCF(FBW7) degrades several proto-oncogenes that function in cellular growth and division pathways, including MYC, cy … WebThe results revealed that FBW7 was negatively correlated with NR4A1 and SCD1 (Fig. 7C, and Fig. S5A). Both NR4A1 and SCD1 were high expression in pancreatic cancer … WebDownload scientific diagram FBW7 inhibits SCD1 transcription via NR4A1. (A) qRT-PCR detected NR4A1 and NR4A2 mRNA in FBW7 T205A or FBW7 R465H overexpressed PANC-1 and SW1990 cells. iss budapest

Fbw7 nr4a1 scd1

The mechanism and progress of ferroptosis in pancreatic cancer

WebAug 31, 2024 · ACSL3 is responsible for the activation of MUFA, which competitively inhibits PUFA-induced ferroptosis. SREBP1-SCD can be activated by the PI3K-AKT-MTOR pathway, a double mutation of STK11 and KEAP1, or the FBW7-NR4A1 pathway. d Zinc ions (Zn 2+) can induce ferroptosis. The inhibition of zinc transporter SLC39A7 on the … WebNr4a1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions …

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WebNov 27, 2024 · The orphan nuclear receptor 4A family is a group of nuclear receptors. In 1988, Milbrandt J identified the nucleotide amino acid sequence of NGFR-B in the search for growth factor-regulated protein factors (Milbrandt, 1988).In the same year, Hazel discovered the NUR77, namely, NR4A1 gene, when using growth factors to stimulate 3T3 … WebAtlanta news, sports, Atlanta weather, entertainment, business and political news from The Atlanta Journal Constitution - What's really going on in Atlanta

WebJan 1, 2016 · Homeowners aggrieved by their homeowners associations (HOAs) often quickly notice when the Board of Directors of the HOA fails to follow its own rules, or otherwise conducts business in manner that appears inconsistent with the Board’s policies and procedures. WebAug 31, 2024 · SREBP1-SCD can be activated by the PI3K-AKT-MTOR pathway, a double mutation of STK11 and KEAP1, or the FBW7-NR4A1 pathway. d Zinc ions (Zn 2+ ) can induce ferroptosis.

Web天上凡星. 这篇文章主要发现了肿瘤抑制蛋白、E3泛素蛋白连接酶FBW7受到诸如电离辐射、氧化物等应激压力时，会降解端粒保护蛋白TPP1，促使端粒暴露和缩短，引发干细胞老化或癌症，以及肺纤维化，而作者合成了一种拟肽类药物TELODIN可以保护端粒、防止端粒 ... WebJan 1, 2024 · FBW7 is correlated with NR4A1 and SCD1 in pancreatic cancer tissues. (A, B) Representative tissue immunofluorescence and IHC staining of FBW7, NR4A1, SCD1 in …

WebAbcam nr4a1 antibody Nr4a1 Antibody, supplied by Abcam, used in various techniques. Bioz Stars score: 80/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more

WebBethyl human igg quantification Human Igg Quantification, supplied by Bethyl, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more iss building timelapseWeb文献「膵癌細胞においてfbw7-nra41-scd1軸はアポトーシスとフェロトーシスを同調的に調節する【jst・京大機械翻訳】」の詳細情報です。j-global 科学技術総合リンクセンターは研究者、文献、特許などの情報をつなぐことで、異分野の知や意外な発見などを支援する新しいサービスです。 iss buffaloWebSep 9, 2024 · They further found that FBW7 activates ferroptosis and ultimately inhibits the proliferation of pancreatic cancer cells by regulating nuclear receptor subfamily 4 group … idiom food for thoughtWebAug 16, 2024 · NR4A1 is an orphan nuclear receptor that belongs to nuclear subfamily 4 (NR4A) receptors. NR4A1 plays an important role in many malignant carcinomas, such as colorectal cancer, breast cancer, … idiom for completing a taskWebMechanistically, we found FBW7 inhibited the expression of stearoyl-CoA desaturase (SCD1) via inhibiting nuclear receptor subfamily 4 group A member 1 (NR4A1). SCD1 was reported to inhibit both ... iss buildingWebNov 24, 2024 · FBW7 is correlated with NR4A1 and SCD1 in pancreatic cancer tissues. (A, B) Representative tissue immunofluorescence and IHC staining of FBW7, NR4A1, SCD1 … idiom for a difficult taskWebJan 1, 2024 · SCD1 was reported to inhibit both ferroptosis and apoptosis, which was consistent with the function of FBW7 and NR4A1, another FBW7 down-regulated gene … iss buffalo ny