Gb3 synthase
WebAug 1, 2024 · The enzyme Gb3 synthase (Gb3S) is required for conversion of LacCer to globotriaosylceramide (Gb3) which can be further glycosylated to generate Gb4. ( b ) In … WebGb3 synthase Feature Type. protein coding gene. IDs. MGI:3512453 NCBI Gene: 239559. Alliance. gene page. Transcription Start Sites. 2 TSS. Location & Maps more. Sequence …
Gb3 synthase
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WebJun 16, 2024 · (A) MDCK cells stably expressing Gb3 synthase were mixed with wild type MDCK cells 1:10, seeded on transwell filters, and cultured for 4 d to form polarized monolayers. LecA-Alexa488 (117 nM) or ... WebDescription. GM3 synthase deficiency is characterized by recurrent seizures (epilepsy) and problems with brain development. Within the first few weeks after birth, affected infants …
WebGlucosylceramide synthase (GCS) catalyzes the first committed step in the biosynthesis of glucosylceramide (GlcCer)-related glycosphingolipids (GSLs). ... of both inhibitors preferentially and significantly reduced the expression of Gb3 in the cancer cell lines IGROV1, BG1, HT29 and T47D, whereas SSEA3 was only reduced in BG1. … WebThis study demonstrated that deletion of Gb3 synthase in mice decreases bone mass via attenuation of bone formation. Glycosphingolipids are known to play a role in developing …
WebMar 6, 2024 · The isolated Gb(3) synthase cDNA encodes a type II transmembrane glycosyltransferase of 360 amino acids. The highest tissue expression of Gb(3) synthase … WebProteintech Anti-A4GALT Polyclonal, Catalog # 12392-1-AP. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF) and Immunohistochemistry (Paraffin) (IHC (P)) applications. This antibody reacts with Human, Mouse samples. Supplied as …
WebApr 23, 2024 · N-glycosylation is a ubiquitous posttranslational modification that may influence folding, subcellular localization, secretion, solubility and oligomerization of …
WebThe isolated Gb3 synthase cDNA encodes a type II transmembrane glycosyltransferase of 360 amino acids. The highest tissue expression of Gb3 synthase RNA is found in the … truck 18 wheelerWebPUF90-03-03. No reviews. 90kg/m³ polyurethane (PU) foam block ideal for composite pattern making. This high density foam can be used to produce sturdier, more detailed … truck 12v dc air conditionerWebIn the presence of Retro-2.1, an inhibitor of intracellular retrograde trafficking, a continuous release of Stx-positive EVs occurred. EVs from HeLa cells possess the Gb3 receptor on their membrane, and EVs from cells that were treated with a glycosylceramide synthase inhibitor, to reduce Gb3, bound significantly less Stx1B. truck 1 year oldGlycosphingolipids (GSLs) are complex lipids consisting of glycans conjugated to a ceramide core and comprise a diverse group of over 300 molecules (Table 1) (D'Angelo et al., 2013; Nakayama et al., 2013). Although the nomenclature and classification of GSLs is complex (1978), they can be classified on … See more Gb3 is a glycosphingolipid formed by a lipid skeleton connected to an oligosaccharide (Figure 1). The lipidic part of its structure consists of the union of a sphingosine and a fatty acid through an amide bond, which … See more Gb3 is present on the cell membrane of a wide variety of mammalian tissue cells. Its expression levels have been associated with pathological or physiological states, depending on whether its canonical ligand Stx participates or … See more Changes in GSLs composition patterns are critical in neural differentiation. It has been previously determined that human embryonic stem cells rich in the globo-series GSLs differentiate into neural cells rich in ganglio-series … See more truck 149 hightruck 0% financingWebMouse fibroblast L cells transfected with SV40 large T antigen and previously cloned Gb3/CD77 synthase cDNAs were co-transfected with a cDNA library prepared from … truck 2 tonWebGb3 synthase KO (Gb3S−/−) mice displayed an increased renal albumin and low molecular weight protein excretion compared to WT. Gb3 localized at the brush border and within vesicular structures in WT proximal tubules and has now been shown to be closely associated with the receptor complex megalin/cubilin and with albumin uptake. truck 12 subwoofer box